HDL isn't called the good cholesterol for nothing. If HDL isn't present to transport harmful LDL cholesterol to the liver for elimination, the LDL will stick to the endothelium and increase the risk for blood-clot formation. Goodman says one recent study found that boosting HDL by a mere 1 percent will cut a woman's cardiovascular disease risk by 3 percent and a man's by 2 percent. He recommends taking supplements that have been proven to raise HDL, including fish oil, niacin, coenzyme Q10, grapeseed extract, and policosanol.